Question: A patient’s nutritional intake and laboratory work reflect hypoalbuminemia.

The solubility of the drug will not match the site of absorption.

There will be less free drug available to generate an effect

Drugs bound to albumin are easily excreted by the kidney.

Question 2. Drugs that have a significant first-pass effect:

It should be administered by the enteral (oral) route only.

Avoid liver circulation

They are rapidly metabolized by the liver and may have little or no desired action.

They are converted by the liver into more active and fat-soluble forms.

Question 3. An advantage of prescribing a sublingual drug is that the drug is:

Quickly absorbed

Quickly excreted

Minimally metabolized

Equally distributed

Question 4. Which of the following statements about bioavailability is true?

Bioavailability issues are especially important for drugs with narrow therapeutic ranges or sustained release mechanisms.

All brands of a drug have the same bioavailability.

Medications that are administered more than once a day have a higher bioavailability than medications that are administered once a day.

The combination of an active drug with an inert substance does not affect the bioavailability.

Question 5. The route of excretion of a volatile drug is likely to be:

The kidneys

Lungs

Bile and feces

The skin

Question 6. The time it takes for the amount of drug in the body to decrease by 50% is called:

Stable state

Half life

Phase II metabolism

Reduction of bioavailability time

Question 7. The elderly are at high risk of adverse reactions due to:

Having greater muscle mass than younger adults, leading to a greater volume of distribution.

The extensive studies that have been conducted on the safety of medications in this age group

The blood-brain barrier is less permeable, requiring higher doses to achieve a therapeutic effect.

Age-related decline in kidney function

Question 8. Patient education regarding prescription drugs includes:

Written Instructions at the High School Reading Level Question 11. Lack of adherence is especially common in medications that treat asymptomatic conditions, such as hypertension. One way to reduce the likelihood of non-compliance with these drugs is to prescribe a drug that:

It has a short half-life, so missing a dose has a limited effect.

Requires multiple dose titrations so that missed doses can be replaced with lower doses to keep costs down

It has a tolerability profile with fewer adverse effects that are considered “irritating”, such as nausea and dizziness.

It should not be taken more than twice a day.

Question 12. A patient can develop neutropenia from the use of topical Silvadene for burns. Neutropenia is:

A cytotoxic hypersensitivity reaction

An immune complex hypersensitivity

An immediate hypersensitivity reaction.

A delayed hypersensitivity reaction